Projects

Food toxicology

Understanding the mechanisms and impacts of food contaminants on biological systems

Chromatin and Transcription

Transcription by RNA polymerase II in the context of chromatin

Bioinformatics and Biostatistics

Tools for the analysis and integration of high throughput data.

Nuclear receptors

Regulation of gene expression in the liver by nuclear receptors

Selected Publications

(2015). Integrator complex regulates NELF-mediated RNA polymerase II pause/release and processivity at coding genes.. Nat Commun. 2014 Nov 20;5:5531..

Project PubMed

(2007). Novel aspects of PPARalpha-mediated regulation of lipid and xenobiotic metabolism revealed through a nutrigenomic study.. Hepatology. 2007 Mar;45(3):767-77..

Project PubMed

Recent Publications

More Publications

(2018). Dual extraction of mRNA and lipids from a single biological sample. Sci Rep. 2018 May;8(1):7019..

Project PubMed

(2017). NO synthesis from arginine is favored by alpha-linolenic acid in mice fed a high-fat diet.. Amino Acids. 2016 Sep;48(9):2157-68..

Project PubMed

(2017). Dietary oleic acid regulates hepatic lipogenesis through a liver X receptor-dependent signaling.. PLoS One. 2017 Jul 21;12(7):e0181393..

Project PubMed

Recent Posts

More Posts

Generating random genome annotations For different purposes, I often need to create random gene/features annotations. I usually need these annotations as a GRanges object (see the GenomicRanges package). I searched a bit on the internet but couldn’t really find what I was looking for. I want to be able to control the following parameters: Number of genes Gene sizes (~gaussian distribution with upper and lower bounds as parameters)

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GGally is an extension of ggplot2. I use it mainly as a replacement/refinement of pairs in base R. Here, I want to replace the default scatter plot used to compare 2 continuous variables with something nicer, especially adapted to plotting large number of points. Load the library and some RNA-seq data: library(GGally) library(airway) data(airway) The airway dataset contains data for 4 cell lines treated or not with dexamethasone:

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Teaching

Some Teaching material:

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